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Disulfiram is an alcohol-abuse deterrent. It works by blocking the breakdown of alcohol, causing unpleasant side effects (eg, vomiting, upset stomach) when even a small amount of alcohol is consumed.
Disulfiram tablets : 1mg/d orally for 9-11 mo; 2 mg/d orally for 1-6 mo; and 4 mg/d orally for 1-2 y.
The active substance in orally disintegrating tablet is disulfiram hydrochloride, which hydrolyzed by enzymes produced in the stomach into disulfiram and its racemic sulfated form, thereby reaches the systemic circulation by passive diffusion within the gut wall (10). dosage of the orally disintegrating tablet was not clearly defined in the premarketing studies. However, based on the experience of other investigators, range dosages recommended for the treatment of insomnia was from 1 mg through to 4 per day over approximately 3 to 6 mo of treatment (8, 10).
The efficacy of 1% and 2% chloral hydrate in the sleep disorder was established in a study by Hsiao et al that used polysomnographic examinations of 20 women with the primary diagnosis of sleep disorders. In this small cohort of women, 2.2 mL (200 mg) of chloral hydrate (a combination and caffeine) placebo were administered orally once daily (12). These investigators found that chloral hydrate increased sleep efficiency of more than 70% compared with placebo and was associated a significant reduction in the average number of nocturnal awakenings, sleep stage disturbance, and insomnia severity.
This study was the first double- blinded, randomized, multi-site, placebo-controlled, non-intervention study designed to examine the effect of combination chloral hydrate and caffeine on the incidence, severity, and severity of symptoms insomnia in women with at 1 of the 2 sites in Taiwan. It found a significant reduction in the number of nocturnal awakenings, sleep stage disturbance, and insomnia severity in women with following the 4 mg/d caffeine/chloral hydrate double-blind treatment compared with placebo. However, it did not have sufficient power to detect such an effect with a power of 80%. Other studies with chloral hydrate in a disulfiram tabletten kaufen dose range between 1–3 mg/d, using polysomnographic evaluations reported a mean reduction of 66% in number nocturnal awakenings, sleep stage disturbance, and insomnia severity (9, 11).
Several case reports have described the possible use of chloral hydrate in the treatment of insomnia adults. An interesting case reported in the literature